Sirolimus-induced pulmonary toxicity without recurrence more than 8 years after everolimus replacement in a renal transplant patient with recurrent skin SCC: a case report

Sirolimus-induced pulmonary toxicity without recurrence more than 8 years after everolimus replacement in a renal transplant patient with recurrent skin SCC: a case report

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Abstract Background Interstitial Pneumonitis (IP) is Poncho/Cape one of the pulmonary complications associated with mammalian Target of Rapamycin-Inhibitors (mTOR-Is).Sirolimus and everolimus belong to mTOR-Is.According to studies, IP is caused by both.

Case presentation This is a case report in a kidney transplant recipient.We want to present a case of IP after 50 months of sirolimus consumption.Sirolimus was discontinued, and cyclosporine was started.

Thirty-seven months later, everolimus was prescribed as an alternative to cyclosporine due to the recurrence of skin Squamous Cell Carcinoma (SCC).Fortunately, no respiratory manifestations were seen after more than Polo Cardigan 8 years of everolimus consumption.Conclusions In conclusion, in cases with sirolimus-induced IP, discontinuation of sirolimus and replacement with everolimus are recommended after resolving clinical symptoms and pulmonary lesions.